Technology

Bilim Pharmaceuticals – Advanced API Manufacturing and Biomanufacturing Excellence

Located in Istanbul, Turkey, Bilim Pharmaceuticals stands at the forefront of the pharmaceutical industry, providing comprehensive solutions across the drug development lifecycle. With a strategic presence across multiple sites and boasting a diverse technological portfolio, Bilim Pharmaceuticals serves as a one-stop shop for all phases of drug development—from preclinical materials to commercial launch products.

Technology and Innovation at Bilim Pharmaceuticals:

  • Multisite Operations: We leverage our multisite infrastructure to support every stage of new drug development efficiently.
  • Continuous Investment: Ongoing investments in our facilities enhance our GMP standards and technological capabilities while expanding manufacturing capacities.
  • Cutting-Edge R&D: Our commitment to research and development is reflected in our work with advanced chemical and biotechnological processes, including flow chemistry, photochemistry, and electrochemistry.
  • Global Manufacturing Excellence: Our expertise is demonstrated across 11 manufacturing plants and 7 research centers worldwide, ensuring that high-level expertise and innovation are shared and applied throughout our network.
  • Technology Transfer and Scale-Up: We ensure seamless technology transitions and scale-ups, providing advanced control and a deep understanding of our clients’ processes from the start.
  • Intellectual Property Management: We actively manage and protect our intellectual property, investing significantly in the security of our technological innovations. Our patent portfolio includes approximately 65 patent families, translating to about 256 patents, encompassing both applications and granted patents.

Advanced High Containment and Payloads (ADC):

  • High Potency Capabilities: Recent investments have significantly enhanced our capacity to develop and manufacture highly potent APIs across all scales throughout the development chain.
  • Ultra-High Containment Production: We are constructing a new facility dedicated to the production of ultra-potent compounds, targeting containment levels up to OEB6, to support advanced therapies such as antibody-drug conjugates.

Biomanufacturing Prowess:

  • Extensive Experience: With over 50 years in microbial fermentation, we possess comprehensive expertise in handling a wide array of biological agents, including bacteria, yeast, and fungi, for both CDMO and proprietary product production.
  • Large-Scale Capacity: Our total fermentation capacity reaches 4,900 m³, supported by a variety of fermenter sizes, making us one of Europe’s largest service providers in microbial fermentation.

Technical and Analytical Capabilities:

  • Diverse Technologies: We employ a broad range of advanced technologies, handling everything from hazardous chemistry to biocatalytic transformations.
  • Analytical and Process Excellence: Our capabilities include photochemical conversions, high-pressure hydrogenations, chromatographic purification, and controlled substance management.

At Bilim Pharmaceuticals, we are committed to advancing pharmaceutical innovation and manufacturing excellence, supporting our clients from initial development through to full-scale commercialization. Our strategic approach ensures that we meet the complex needs of the generic and innovative pharmaceutical sectors, driving forward the global healthcare industry.